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Straterra (atomoxetine) is a norepinephrine uptake inhibitor used to treat ADHD. It is approved for use in kids and adults. Strattera increases norepinephrine and dopamine in the frontal cortex of the brain.

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How Atomoxetine is Taken

Atomoxetine is started at a total daily dose of 0.5 mg/kg and increased after a minimum of 3 days to a target total daily dose of 1.2 mg/kg administered either as a single daily dose in the morning or as evenly divided doses in the morning and late afternoon/early evening. After 3 additional weeks, the dose may be increased to a maximum of 100 mg in people who have not achieved an optimal response.

How does Strattera affect the body

What is known is that Strattera causes an increase in the brain of levels of a hormone known as "norepinephrine". Norepinephrine is very similar to its cousin adrenaline. Atomoxetine is rapidly absorbed, with peak circulating levels reached approximately 1-2 hours after dosing. Atomoxetine's metabolite is excreted mainly in the urine (>80% of the original dose) and to a lesser extent in the feces (<17% of the original dose). At the two higher doses, improvements in ADHD symptoms were significantly superior in atomoxetine-treated patients compared with placebo-treated patients.

Strattera Drug Interactions

There have been reports of serious reactions (including severe fever, rigidity, rapid fluctuations of vital signs, and behavioral changes) when taken in combination with MAO inhibitors. Atomoxetine needs to be administered with caution to patients being treated with oral or intravenous albuterol because the action of albuterol on the heart can be strengthened, resulting in increased heart rate and blood pressure.

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