Olanzapine is effective in relieving both positive and negative symptoms of schizophrenia, whereas the conventional antipsychotics are usually less effective against the negative symptoms. Olanzapine is also used to treat moderate to severe episodes of mania in people with bipolar affective disorder (manic depression). Zyprexa may also be used long-term as a mood stabiliser to prevent further manic and depressive episodes of bipolar disorder.
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Side effects cannot be anticipated. If the doctor suggests certain regular diagnostic check up or blood tests for evaluating the progress and side effects of the drug, don't ignore doing that. Certain antipsychotic drugs, including Zyprexa, are associated with an increased risk of developing high blood sugar, which on rare occasions has led to coma or death. See your doctor right away if you develop signs of high blood sugar, including dry mouth, unusual thirst, increased urination, and tiredness.
Zyprexa, like the other atypical antipsychotics, appears to work by by blocking certain serotonin and dopamine receptors. Unlike some other medications it blocks the serotonin receptors more potently than the dopamine receptors. Olanzapine works by blocking the receptors in the brain that dopamine acts on. This prevents the excessive activity of dopamine and helps to control schizophrenia.
This medication can be unbelievably effective, with remarkably few side effects. But brace yourself, and don't stop reading until the end of this little essay because there may be some good news in sight. Side effects of olanzapine can include: weight gain, difficulty swallowing, irritability, dry mouth, seizures, irregular menstrual cycles, urinary retention, elevated blood pressure, restlessness, and runny nose. Patients can also develop tardive dyskinesia, in which they experience involuntary muscle movements, especially if they have been taking the drug for a prolonged period at a high dosage. These side effects were common in older antipsychotic medications, and include restlessness, slowing of some movements, decreased facial expressions, tremor or rigidity of arms and head, and muscle tissue toxicity.