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Fluconazole is a type of medicine called an antifungal. It is used to treat or prevent infections caused by certain types of yeast or fungus.

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Dosage And Administration In Children

Doses up to 12 mg/kg/day may be used based on medical judgment of the patient's response to therapy. Diflucan should be discontinued if clinical signs and symptoms consistent with liver disease develop that may be attributable to Diflucan. Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. During post-marketing surveillance, there have been rare cases of QT prolongation and torsade de pointes in patients taking fluconazole. Most of these reports involved seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities and concomitant medications that may have been contributory.

Fluconazole Precautions

Clinically significant hypoglycemia may be precipitated by the use of Diflucan with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined Diflucan and glyburide use. In post-marketing experience, as with other azole antifungals, bleeding events (bruising, epistaxis, gastrointestinal bleeding, hematuria, and melena) have been reported in association with increases in prothrombin time in patients receiving fluconazole concurrently with warfarin. Because of the occurrence of serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, interaction studies have been performed.

Taking Diflucan with other medicines

There are some medicines that should not be taken together with fluconazole or in some cases the dose of fluconazole or other medicines may need to be adjusted.

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