Metformin was approved for use in the U.S. for treatment of type 2 diabetes. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower your blood sugar to a normal level.
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Glucophage therapy should be initiated at 500 mg once daily in patients on insulin therapy. For patients not responding adequately, the dose of Glucophage or Glucophage should be increased by 500 mg after approximately 1 week and by 500 mg every week thereafter until adequate glycemic control is achieved.
In about 25% of women metformin causes side effects which may include abdominal discomfort, cramping, diarrhea and nausea. The side effects may be severe enough to make the woman stop the metformin medication. We are not aware of any serious complications resulting from metformin treatment. Another oral medication used for diabetes called Troglitazone has been associated with liver failure and death in rare cases. This has been publicized on television shows, in newspapers, etc. Some women will have polycystic ovarian syndrome and irregular or absent menstrual periods regardless of their weight.